3-O-Ethyl-L-ascorbic acid


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  • 3-O-Ethyl-L-ascorbic acid
  • 86404-04-8
  • C<sub>8</sub>H<sub>12</sub>O<sub>6</sub>
  • 204.18
Inquiry

Quality Manufacturer Supply 86404-04-8, Buy Reliable Quality Ethyl Ascorbic Acid with Cheapest Price

  • Molecular Formula:C8H12O6
  • Molecular Weight:204.18
  • Vapor Pressure:1.84E-14mmHg at 25°C 
  • Melting Point:112.0 to 116.0 °C 
  • Refractive Index:1.555 
  • Boiling Point:551.5 °C at 760 mmHg 
  • PKA:8.89±0.40(Predicted) 
  • Flash Point:228.5 °C 
  • PSA:96.22000 
  • Density:1.46 g/cm3 
  • LogP:-0.92890 

3-O-Ethyl-L-ascorbic acid(Cas 86404-04-8) Usage

Mechanism of action

VC ethyl ether penetrates the stratum corneum to reach the melanocytes in the basal layer, inhibits tyrosinase activity, inhibits the formation of melanin, and restores melanin to colorless, thereby effectively whitening the skin. And lookchem and VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen, so that the skin becomes full and elastic, making the skin delicate and smooth.

Synthesis

The above 3-O-ethyl-5,6-O-isopropylideneascorbic acid 40g dissolved in 200ml of ethanol. 10g of cation-exchange resin was added and was refluxed for 2 hours. The catalyst was removed by an ion exchange resin and concentrated under reduced pressure. After drying, with ethyl acetate: hexane (3: 1) crystallization. After drying, obtained 33.3g 3-O-ethylascorbic acid, yield 94%. It was recrystallized in 100mL ethyl acetate giving 30.6g, yield 87%, mp: 112-114°C.

Consumer Uses

This substance is used in the following products: cosmetics and personal care products. Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

InChI:InChI=1/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1

86404-04-8 Relevant articles

A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid

Tai, Akihiro,Aburada, Mei,Ito, Hideyuki

, p. 1984 - 1987 (2014)

A single-step synthesis of 3-O-ethyl-L-a...

a method for manufacturing 3-O-alkyl-ascorbic acid

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Paragraph 0130; 0140-0144; 0157-0160, (2021/12/03)

3 - O - Alkyl - ascorbic acid. 3 - O -al...

Vitamin C ethyl ether synthesis method

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Paragraph 0021-0038, (2021/05/12)

The invention discloses a vitamin C ethy...

Method for synthesizing 3-O-alkyl-5,6-O-isopropylidene ascorbic acid by using circulation method

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Paragraph 0043; 0044, (2019/10/29)

The invention provides a method for synt...

Crystal form A of 3-O-ethyl-L-ascorbic acid, its preparation method and whitening composition

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Paragraph 0054; 0061; 0064, (2019/10/17)

The present invention relates to the fie...

86404-04-8 Process route

(R)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-ethoxy-3-hydroxyfuran-2(5H)-one
86404-03-7

(R)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-ethoxy-3-hydroxyfuran-2(5H)-one

3‐O‐ethyl‐L‐ascorbic acid
86404-04-8

3‐O‐ethyl‐L‐ascorbic acid

Conditions
Conditions Yield
With hydrogenchloride; In methanol; at 60 ℃; for 3h;
98%
With hydrogenchloride; In methanol; water; at 60 ℃; for 3h;
98%
With cation-exchange resin; In ethanol; for 2h; Reflux;
87%
With hydrogenchloride; water; at 60 ℃; for 2h; Product distribution / selectivity;
84.3%
With hydrogenchloride; In propan-1-ol; at 60 ℃; for 2h;
56%
With hydrogenchloride; Nafion H; water; In ethanol; at 60 ℃; for 2h; not specified Product distribution / selectivity;
 
With water; In ethanol; at 60 ℃; for 2h; Product distribution / selectivity;
 
With hydrogenchloride; In methanol; water; at 20 ℃; for 16h;
 
With toluene-4-sulfonic acid; In ethanol; at 60 ℃; for 2h; Solvent;
 
ethanol
64-17-5

ethanol

ascorbic acid
50-81-7,98966-42-8

ascorbic acid

3‐O‐ethyl‐L‐ascorbic acid
86404-04-8

3‐O‐ethyl‐L‐ascorbic acid

Conditions
Conditions Yield
ascorbic acid; With tetrabutylammomium bromide; tin(IV) chloride; In ethyl acetate; at 40 ℃;
ethanol; With triethylamine; Diethyl carbonate; at 45 ℃; for 5h;
With hydrogenchloride; In water; at 55 ℃; pH=2; Temperature; pH-value;
76%

86404-04-8 Upstream products

  • 86404-03-7
    86404-03-7

    (R)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-ethoxy-3-hydroxyfuran-2(5H)-one

  • 64-67-5
    64-67-5

    diethyl sulfate

  • 50-81-7
    50-81-7

    ascorbic acid

  • 62-50-0
    62-50-0

    Ethyl methanesulfonate

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