What is the Sugammadex sodium?

Sugammadex sodium is , while it's Molecular Formula is C72H104Na8O48S8. Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.

What is the CAS number for Sugammadex sodium?

The CAS number of Sugammadex sodium is 343306-79-6.

What is Sugammadex sodium (343306-79-6) used for?

To facilitate tracheal intubation, mechanical ventilation, and surgicalaccess, NMB agents are frequently used as non-anesthetic adjuncts insurgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizingneuromuscular blocker, without the cardiovascular adverse effectsexperienced with reversal agents that directly interact with thecholinergic system. The γ-cyclodextrin has been designed to enhancebinding of the guest by incorporating acidic side chains to promote anelectrostatic interaction with the positive nitrogen of the blocker. Startingwith γ-cyclodextrin, these side chains are readily installed by firsthalogenating with iodine or bromine to provide a handle for nucleophilicdisplacement with either 3-mercaptopropionic acid in the presence ofsodium hydride or with 3-mercaptopropionic acid methyl esterand cesium carbonate. The latter requires hydrolysis with sodiumhydroxide to generate sugammadex sodium.