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1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

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  • 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
  • 1792180-81-4
  • 285.349
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Chinese Manufacturer Supply High Purity 99% 1792180-81-4 with Safe Delivery

  • Molecular Formula:C15H19N5O
  • Molecular Weight:285.349
  • PKA:13.03±0.50(Predicted) 
  • Density:1.272±0.06 g/cm3(Predicted) 

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1792180-81-4 Process route

N-((3R,6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-((3R,6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

(-) 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1792180-81-4

(-) 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

Conditions
Conditions Yield
N-((3R,6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; With potassium phosphate; In tetrahydrofuran; water; at 18 - 53 ℃; for 0.166667h; Large scale;
2-chloropropionyl chloride; In tetrahydrofuran; water; at 10 - 20 ℃; for 2h; Large scale;
With potassium dihydrogenphosphate; In tetrahydrofuran; water; at 20 ℃; for 0.166667h; Large scale;
81%
N-((3R,6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 2-chloropropionyl chloride; With potassium phosphate; In tetrahydrofuran; water; at 10 - 20 ℃; for 2h; Inert atmosphere; Large scale;
With water; sodium hydroxide; In tetrahydrofuran; at 22 - 25 ℃; Inert atmosphere; Large scale;
81%
tert-butyl 4-((3R, 6S)-1-acryloyl-6-methylpiperidin-3-ylamino)-7H-pyrrolo[2,3-d]-pyrimidine-7-carboxylate

tert-butyl 4-((3R, 6S)-1-acryloyl-6-methylpiperidin-3-ylamino)-7H-pyrrolo[2,3-d]-pyrimidine-7-carboxylate

(-) 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1792180-81-4

(-) 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

Conditions
Conditions Yield
With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 4h;
94.8%

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    acryloyl chloride

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    tert-butyl N-(6-methylpyridin-3-yl)carbamate

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